5-Fluorouracil purchased from MCE. Usage Cited in:

Nat Med. 2024 Mar;30(3):749-761.

[Abstract]

The relative cell viability of shCtl-, shNDUFB8-, and shCEMIP2-transfected cells was detected by XTT assay after paclitaxel plus gemcitabine treatment (A+G), single-agent 5-Fu (5-FU), and the FOLFIRINOX chemotherapy cocktail [FU+IRI+OXA: 5-FU (5 μM)+Irinotecan (SN-38) +Oxaliplatin] for 48h.

5-Fluorouracil purchased from MCE. Usage Cited in:

Cell. 2024 Apr 25;187(9):2288-2304.e27.

[Abstract]

SP1 and SLC6A6 levels in SGC7901 cells treated with fluorouracil (0.5 μg/mL) for the indicated times.

5-Fluorouracil purchased from MCE. Usage Cited in:

Mol Cancer. 2024 Jan 24;23(1):23.

[Abstract]

A CCK-8 assay was used to investigate the effects of LINC01852 overexpression and knockdown on the sensitivity of CRC cells to 5-FU and L-OHP. CRC cells were exposed to gradually increasing concentrations of 5-FU (1-3 μM) and L-OHP for 48 h

5-Fluorouracil purchased from MCE. Usage Cited in:

ACS Nano. 2023 Nov 8.

[Abstract]

5-FU (120 mg/kg; i.p.; once daily for 2 consecutive days) induces increased infiltration of CD45+ immune cells into the intestinal lumen of Dgcr8-deficient mice, accompanied by elevated levels of the pro-inflammatory cytokines IFNγ and pNF-κB.

5-Fluorouracil purchased from MCE. Usage Cited in:

Adv Sci (Weinh). 2022 Oct;9(30):e2200717.

[Abstract]

A transient upregulation and subsequent downregulation of RSK2 phosphorylation at Thr577 by 5-Fluorouracil (5-FU), which is accompanied by the accumulation of γ‐H2AX phosphorylation in a time‐dependent manner.

5-Fluorouracil purchased from MCE. Usage Cited in:

Adv Sci (Weinh). 2022 Oct;9(30):e2200717.

[Abstract]

In Hct116 cells, the inhibitory effects of 5-Fluorouracil (5-FU on cell growth at 2-10 μM are significantly enhanced by RSK2 or PAK4 inhibitors in short‐term and long‐term assays.

5-Fluorouracil purchased from MCE. Usage Cited in:

J Immunother Cancer. 2022 Aug;10(8):e004006.

[Abstract]

Hep3B and Huh7 cells are treated with 5-Fluorouracil for 24 h, then the cellular protein expression of p-IRF3 and pP65 is detected by immunoblotting.

5-Fluorouracil purchased from MCE. Usage Cited in:

Int J Biol Sci. 2022 Apr 11;18(7):2882-2897.

[Abstract]

Representative immunoblots assessing apoptosis induced by 5-Fluorouracil (5-FU) in immortalized human ventricular myocytes (AC16).

5-Fluorouracil purchased from MCE. Usage Cited in:

Gastroenterology. 2021 Nov;161(5):1601-1614.e23.

[Abstract]

Bar graphs show the GI50 of 5-fluoruracil (48 h), irinotecan (48 h), gemcitabine (48 h), paclitaxel (48 h), and oxaliplatin (48 h) in PDAC cells in combination with bioactive hexapeptides (NTAIYY and PTTIYY) or controls (saline and NTAIYA).

5-Fluorouracil purchased from MCE. Usage Cited in:

Adv Sci (Weinh). 2021 Nov;8(21):e2101936.

[Abstract]

Cell viability upon treatment with 5-Fluorouracil (5-FU; 60 μM), SR140333, or Aprepitant either as single agents or in combination at 24 h in HCT116 cells.

5-Fluorouracil purchased from MCE. Usage Cited in:

Adv Sci (Weinh). 2021 Nov;8(21):e2101936.

[Abstract]

ER stress pathways in HCT116/5-FU cells treated with 5-Fluorouracil (5-FU; 60 μM) with SR140333 or Aprepitant either as single agents or in combination at 24 h.

5-Fluorouracil purchased from MCE. Usage Cited in:

Adv Sci (Weinh). 2021 Nov;8(21):e2101936.

[Abstract]

Western blotting of drug-resistant proteins in HCT116/5-FU cells treated with 5-Fluorouracil (5-FU; 80 μM) at 48 h.

5-Fluorouracil purchased from MCE. Usage Cited in:

Adv Sci (Weinh). 2021 Nov;8(21):e2101936.

[Abstract]

The combination of SR140333 or aprepitant and 5-Fluorouracil (5-FU; mg/kg) decreases the expression levels of ABCC1, ABCG2, p-ERK1/2, and c-Myc and increased those of p-PERK, ATF4, and CHOP compared with 5-FU treatment alone.

5-Fluorouracil purchased from MCE. Usage Cited in:

J Exp Clin Cancer Res. 2021 Apr 30;40(1):150.

[Abstract]

Inhibition rate of proliferation in pcDNA3.1 or ZBTB28 transfected cells treated with gradient concentration of 5-FU for 72 hours.

5-Fluorouracil purchased from MCE. Usage Cited in:

Cell Death Dis. 2021 Apr 1;12(4):338.

[Abstract]

SW620, CACO2, and HCT15 cells are treated with different concentrations of UTD1 and 5-Fluorouracil (5-FU), and cell viability is measured by CCK-8.

5-Fluorouracil purchased from MCE. Usage Cited in:

Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2026813118.

[Abstract]

Overexpression of RMRP impairs 5-FU-induced p53 activation determined by IB.

5-Fluorouracil purchased from MCE. Usage Cited in:

Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2026813118.

[Abstract]

Overexpression of RMRP impairs 5-FU–induced p53 activation determined by RT-qPCR.

5-Fluorouracil purchased from MCE. Usage Cited in:

Int J Biochem Cell Biol. 2018 Mar;96:9-19.

[Abstract]

Hep3B cells are treated with 2 μmol Shikonin, 5-FU, BSNQ or OSNQ for different times (3, 6, 12 and 24 h), and stained with Annexin V and PI. The apoptotic cells are detected by fluorescence microscopy and quantified as percentages.

5-Fluorouracil purchased from MCE. Usage Cited in:

J Cell Biochem. 2018 Nov 28.

[Abstract]

The expressions of apoptotic-related proteins, cleaved-PARP, caspase-3-active and survivin are detected in MKN45, MKN45+5-Fu, MKN45-EV, MKN45-DEC2, MKN45-DEC2+5-Fu, MKN28, MKN28+5-Fu, MKN28-EV, MKN28-DEC2, MKN28-DEC2+5-Fu cells using Western blot analysis.

5-Fluorouracil purchased from MCE. Usage Cited in:

J Cell Biochem. 2018 Nov 28.

[Abstract]

The expressions of apoptotic-related proteins, cleaved-PARP, caspase-3-active are detected in control, STAT5A, STAT5A+5-Fu, DEC2+5-Fu, DEC2/STAT5A+5-Fu of MKN45 and MKN28 cell lines using Western blot analysis.

5-Fluorouracil purchased from MCE. Usage Cited in:

J Cell Biochem. 2018 Nov 28.

[Abstract]

MKN45 and MKN28 cells transfected with empty and DEC2 vectors are incubated in control medium or 5-Fu of 10 μM for 48 hours, then proliferation ratio of these cells is figured by EdU incorporation assay.

5-Fluorouracil purchased from MCE. Usage Cited in:

Biochem Biophys Res Commun. 2018 Jun 27;501(3):636-642.

[Abstract]

Immunoblot analysis of the expression levels of BCL-2 and BAX after treatment of HCT116 TP53-/- cells with 20 μM 5-FU and 1.25 μM DHA alone or in combination for 48 h. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) served as a loading control.

5-Fluorouracil purchased from MCE. Usage Cited in:

Med Sci Monit. 2018 Sep 21;24:6666-6672.

[Abstract]

Expression of protein of OPA1, Mfn1, Mfn2, Drp1 and Fis1 in heart mitochondria of rats treated with different 5-FU concentrations. The control group is intraperitonealled injection with same amount of physiological saline.

5-Fluorouracil purchased from MCE. Usage Cited in:

Tumour Biol. 2016 Jul;37(7):8811-24.

[Abstract]

Assays for autophagy activity. Immunoblot analysis for LC3B. Compared with the Lenti-NC cells, the Lenti-CD44v6 cells display a higher intensity of autophagy flux but not steady-state levels when treated with 5-FU (*P<0.001).